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Image Search Results
Journal: bioRxiv
Article Title: Mutagenesis and homology modeling reveal a predicted pocket of lysophosphatidylcholine acyltransferase 2 to catch Acyl-CoA
doi: 10.1101/2020.10.31.363515
Figure Lengend Snippet: A) A region of tmPlsC, mLPCAT and mLPCAT2 containing conserved regions, i.e., AGPAT motifs 1 (green), 2 (magenta), 3 (blue), and 4 (orange), was used as a query for GENETYX-MAC software. The amino acid residues analyzed by mutagenesis in this study are indicated with red open squares. Asterisks represent conserved residues, and dots represent weakly similar residues. B) Schematic representations of the structures of tmPlsC, mLPCAT1, and mLPCAT2. Motifs 1– 4 are colored green, magenta, blue, and orange, respectively. We modeled mLPCAT1 (light green domain) and mLPCAT2 (light blue domain) based on the crystal structure data for tmPlsC (beige). C) Homology modeling of mLPCAT1 and mLPCAT2. Ribbon models of tmPlsC (used as the template), mLPCAT1, and mLPCAT2. Motifs 1–4 are highlighted as follow: motif 1, green; motif 2, magenta; motif 3, blue; motif 4, orange.
Article Snippet: Sequence alignments were generated using
Techniques: Software, Mutagenesis